Witcher 3: Every Mutation, Ranked By Their Usefulness (2023)

The Blood and Wine expansion added a lot to The Witcher 3, including new characters, the Skellige Gwent deck, and one of the most beautiful locations in the game, Toussaint. Another excellent addition, though, was the mutations. These powerful new abilities became the focal point of every The Witcher 3 character build going forward.

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There are 12 mutations in total, which all have their own distinct ways of improving the player. But they are not created equal. Some of them are far more useful than others. And as players can only equip one at a time, it's important to know which are the best mutations in The Witcher 3.

Updated February 1, 2022 by Mark Sammut: Despite debuting more than half a decade ago, The Witcher 3 still averages above 15,000 simultaneous players on Steam, and that's not counting periods during or after sales that give the game a substantial boost. CD Projekt Red is reportedly working on a standalone Gwent game, so Witcher fans have a lot to look forward to in 2022. Whether someone is playing through the RPG and its expansions for the first or tenth time, they will come across mutations when they get to the Blood and Wine DLC. This article has been expanded to provide more information about each mutation.

Strengthened Synapses

Strengthened Synapses is a mutation that improves as Geralt researches the active mutations. As such, it is not really comparable to the other ones, even though it is arguably the most important in the grand scheme of things.

Strengthened Synapses allows Geralt to equip more abilities, although they would need to be of the same type (color) as the equipped active mutation:

Green

Alchemy

Blue

Signs

Red

Combat

Some mutations have a mix of colors, allowing a wider range of abilities to be equipped. If Second Life or Metamorphosis is active, any ability can be chosen.

12/12 Adrenaline Rush

Witcher 3: Every Mutation, Ranked By Their Usefulness (1)

Type

Combat & Signs

Ability Points Required

5

Mutagens Required

  • 3 Greater Blue
  • 2 Greater Red

Mutations That Must Be Unlocked

  • Piercing Cold
  • Bloodbath

The main issue with Adrenaline Rush is how long it takes to unlock. Players need to have Piercing Cold and Bloodbath simply to get their hands on this one. And it's not worth the effort, never mind the mutagens and ability points it costs.

The mutation increases the player's attack power and sign intensity by 30% per enemy. So if they're taking on five foes, their damage will be boosted by 150%, which is a lot. But the catch is that it only lasts 30 seconds. After that, it becomes a hindrance as players' damage drops by 10% per foe instead.

11/12 Mutated Skin

Witcher 3: Every Mutation, Ranked By Their Usefulness (2)
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Type

Combat & Alchemy

Ability Points Required

5

Mutagens Required

  • 3 Greater Green
  • 2 Greater Red

Mutations That Must Be Unlocked

Euphoria

With Mutated Skin, each adrenaline point decreases damage received by 15%. So in total, players can improve their defense by 45%.

Not bad, however, there are multiple basic skills that players can pick up to increase their survivability. They shouldn't have to rely on their mutation and adrenaline points to keep them safe during the most difficult battles in the game. Especially as beyond making them tougher, Mutated skin doesn't help players in any other way.

10/12 Toxic Blood

Type

Alchemy

Ability Points Required

2

Mutagens Required

2 Greater Green

Considering Toxic Blood is one of the cheapest mutations; it's not that bad. How it works is every time Geralt takes a hit in combat, the attacker will receive 1.5% of damage for every point of toxicity the Witcher has. Therefore, if their toxicity bar is full (before it's enhanced with skills or certain armor), then the people who strike the player will take 150% damage.

That's a hell of a lot of punishment to deal out just by getting attacked. However, that's the problem, players need to take a beating to use it, which on harder difficulties is dangerous.

9/12 Cat Eyes

Witcher 3: Every Mutation, Ranked By Their Usefulness (4)

Type

Combat & Alchemy

Ability Points Required

5

Mutagens Required

  • 3 Greater Green
  • 2 Greater Red

Mutations That Must Be Unlocked

  • Euphoria
  • Bloodbath

Every player knows that unless they're underwater, the crossbow is pretty useless. However, that changes once Cat Eyes is equipped.

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The mutation gives a significant increase to the effectiveness of the ranged weapon by boosting its power and critical chance. And in the right hands with some strong bolts, it can turn the crossbow into a truly deadly part of a player's arsenal. Although, it doesn't help with the game's many close-quarters fights.

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8/12 Deadly Counter

Witcher 3: Every Mutation, Ranked By Their Usefulness (5)

Type

Combat

Ability Points Required

2

Mutagens Required

2 Greater Red

The Deadly Counter mutation is fun and deadly at the same time. With it, finishers become a lot more prevalent as counterattacking anyone whose health is below 25% immediately triggers one.

It also gives a 25% boost to sword strikes against those immune to counterattacks as well as all monsters - no matter how strong they are. Those are some decent bonuses, but they aren't as impressive as what some of the best mutations have to offer.

7/12 Bloodbath

Witcher 3: Every Mutation, Ranked By Their Usefulness (6)

Type

Combat

Ability Points Required

3

Mutagens Required

3 Greater Red

Mutations That Must Be Unlocked

Deadly Counter

For every melee strike players land with the Bloodbath mutation equipped, they get a 5% boost to their attack power. Hit enough people, and players can obtain an insane 250% increase in damage.

While it seems incredibly deadly, there is a major drawback. Once players get hit, the boost resets, thus reaching the maximum damage output is rare. But those skilled in the art of dodging and parrying can inflict a lot of pain with this mutation.

6/12 Second Life

Witcher 3: Every Mutation, Ranked By Their Usefulness (7)

Type

Combat, Signs, & Alchemy

Ability Points Required

7

Mutagens Required

  • 3 Greater Red
  • 2 Greater Blue
  • 2 Greater Green

Mutations That Must Be Unlocked

Adrenaline Rush

Second Life is like a safety net (albeit one with a 180-second cooldown), as once players die, the mutation makes them invulnerable as their health regens back to 100%.

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The usefulness of this depends on the player. A revival power is pointless for those who rarely ever die in the game. Yet, for the players who struggle to contend with all the creepy monsters roaming around in The Witcher 3, then this mutation is a literal life-saver.

5/12 Magic Sensibilities

Witcher 3: Every Mutation, Ranked By Their Usefulness (8)

Type

Signs

Ability Points Required

2

Mutagens Required

2 Greater Blue

Despite being one of the cheapest mutations, Magic Sensibilities is up there with the best. It gives players the chance to get a critical hit with their magical signs. And the frequency and damage of those criticals improve based on the sign intensity of the player.

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As signs are a significant part of a Witcher's arsenal, this mutation is a nice way of making them more useful on harder difficulties.

Witcher 3: Every Mutation, Ranked By Their Usefulness (9)

Type

Combat, Signs, & Alchemy

Ability Points Required

7

Mutagens Required

  • 3 Greater Green
  • 2 Greater Blue
  • 2 Greater Red

Mutations That Must Be Unlocked

Cat Eyes

Metamorphosis is an interesting mutation, as once equipped, every time players apply a critical effect, it randomly triggers a decoction without causing any toxicity. So it's possible to stack a bunch of the most powerful ones together.

Now, there is a random element to what decoctions are consumed, but it's only between those that players have previously brewed. Therefore, as long as players aren't making pointless decoctions (they can also drop the useless ones), then Metamorphosis can be very useful. As a bonus, the mutation also gives players better vision in the dark, meaning there's no need for cat potions or torches.

3/12 Conductors Of Magic

Witcher 3: Every Mutation, Ranked By Their Usefulness (10)
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Type

Combat & Signs

Ability Points Required

5

Mutagens Required

  • 3 Greater Blue
  • 2 Greater Red

Mutations That Must Be Unlocked

Piercing Cold

For players who want to make their signs as powerful as possible, Conductors of Magic is a necessity.

Conductors of Magic adds 50% of their equipped sword's damage to their sign damage. Although, on the condition that it's either a magic, unique, or witcher sword, which isn't much of an issue as those are the best in the game. When the mutation is paired with a sword that has a very big damage output, signs become a lot more lethal than usual.

2/12 Piercing Cold

Witcher 3: Every Mutation, Ranked By Their Usefulness (11)

Type

Signs

Ability Points Required

3

Mutagens Required

3 Greater Blue

Mutations That Must Be Unlocked

Magic Sensibilities

When using the Piercing Cold mutation, Aard has a 25% chance of freezing enemies. And once frozen, the opponents die immediately upon hitting the ground. Even those who are lucky enough to avoid the elemental effect still take an incredible amount of damage.

The mutation alone makes Aard extremely effective. But pairing it with skills that boost the strength of the sign makes it one of the most destructive powers in the game.

1/12 Euphoria

Witcher 3: Every Mutation, Ranked By Their Usefulness (12)

Type

Alchemy

Ability Points Required

3

Mutagens Required

3 Greater Green

Mutations That Must Be Unlocked

Toxic Blood

There's no question that Euphoria is one of the most overpowered abilities in The Witcher 3. Therefore, it's definitely the most useful mutation. With Euphoria, each point of toxicity improves both the player's sword and sign damage by 0.75%.

Initially, it doesn't sound like much. However, when paired with skills that increase a player's maximum toxicity such as Metabolism Control and Acquired Tolerance, and after drinking some strong decoctions, the damage output soon adds up. And players can make quick work of even the toughest opponents in the game.

The Witcher 3 is available on PS4, Xbox One, Switch, and PC. PS5 and Xbox Series X/S versions of the game are also in development.

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FAQs

Which mutations are the best Witcher 3? ›

There's no question that Euphoria is one of the most overpowered abilities in The Witcher 3. Therefore, it's definitely the most useful mutation. With Euphoria, each point of toxicity improves both the player's sword and sign damage by 0.75%.

What do I do with all the mutagens? ›

Activate mutagens by placing them in the diamond-shaped slots on the Character panel. Next to each slot is a set of square Ability slots. Activated mutagens grant special bonuses to your character statistics. Different types (colors) of mutagens grant different kinds of bonuses.

What are all of Geralt's mutations? ›

After displaying unusual tolerance, Geralt was selected to further experimental mutations which granted him considerably greater strength, speed, endurance, resilience, healing, senses, complete immunity to diseases and conventional poisons, and extreme resistance to pain.

What is the most powerful sword in Witcher 3? ›

The Black Unicorn Relic Steel Sword is often regarded as the best weapon to kill human enemies in The Witcher 3. The sword can only be utilized by players who are at level 46 or higher, and the diagram for crafting the Black Unicorn Relic Steel Sword can be found hidden near Kaer Morhen.

What is the most powerful Witcher 3 build? ›

The Witcher 3 best builds
  • Euphoria build (arguably the most powerful; emphasises alchemy and swordplay)
  • Full Combat build (emphasises pure physical damage; a glass cannon build)
  • Versatile Tank build - (a mixture of leanings with an emphasis on survivability)
Dec 20, 2022

How much mutagen does 800 Mutagel make? ›

Mutagen needs Mutagen to exist, as you can craft six Mutagen from 800 Mutagel by using a Chemistry Bench.

How many times can you use mutagen? ›

Mutagen can be used only once on a creature.

Can you craft Red mutagens? ›

How to Craft Red Mutagens. The alternative is to craft your own mutagens in the alchemy menu, though you can only do this with the Blood and Wine DLC. By going to the merchant in Hauteville, Toussaint, players can buy formulas that show how to turn other green and blue mutagens into red ones.

How old is Geralt when he dies? ›

Geralt is around 90 - 100 years old. Yennefer is around 110, while Triss is way younger (around 50). Ciri is around 25 in most of the TW3 (except the beginning of course where she should be around 12).

Is Geralt extra mutated? ›

Geralt is a result of his exposure to further mutation, due to his unique tolerance for the Trial of Grasses; this extended process left his hair devoid of pigment and possibly left him even stronger and faster than his brethren. How this process was developed is a mystery even to the Witchers themselves.

Who is Geralt's true love? ›

Geralt of Rivia

What is the most drastic mutation? ›

Frameshift mutations are generally much more serious and often more deadly than point mutations. Even though only a single nitrogen base is affected, as with point mutations, in this instance, the single base is either completely deleted or an extra one is inserted into the middle of the DNA sequence.

Is human mutation possible? ›

Numerous lines of evidence, many based on whole-genome sequencing of parent–offspring trios, show that the average human mutation rate is in the range of 1.1–1.7 × 108 per nucleotide site per generation for base-substitution mutations alone (Lynch 2009; Campbell et al.

What is GABA mutation? ›

Mutations in inhibitory GABAA receptor subunit genes (GABRA1, GABRB3, GABRG2 and GABRD) have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), juvenile myoclonic epilepsy (JME), pure febrile seizures (FS), generalized epilepsy with febrile seizures plus (GEFS+), and Dravet ...

What is the holiest sword? ›

Durandal. Durandal is the legendary Holy Sword of destruction that was first wielded by Gabriel, before giving to Charlemagne which was soon given to the Paladin Roland, who used it to fight off over 100,000 Muslims so Charlemagne's army could retreat into France.

What is the greatest sword of all time? ›

1. Excalibur: The Most Famous Legendary Sword. Arthur Pendragon, ruler of the Britons, was said to have drawn this legendary sword from a stone and anvil when no one else could — at least in most tellings of the legend.

What is the most cursed sword? ›

What is the most cursed sword in the world? The Muramasa is a Japanese Katana sword known as cursed and demonic. It is a real historical sword surrounded by terrifying legends and stories.

Is 100 the max level in Witcher 3? ›

When playing the base game on its own or with the Hearts of Stone expansion, Geralt's max level is 70. However, the large Blood and Wine expansion increases this cap up to level 100. This is an extremely generous cap because players will most likely end the game with a level of around 50.

Is Yennefer the strongest sorcerer? ›

The elven-blooded Yennefer of Vengerberg is often considered the most powerful living sorceress, having pushed beyond her initial struggles with magic to learn how to control her Chaos, granting her considerable power.

What is the most powerful armor in Witcher 3? ›

Many players consider the Feline School gear to be the very best of the armour on offer in The Witcher 3, and they are all correct.

Is there a max mutations ark? ›

Probability of Mutation. For each offspring up to three mutations can occur, each with a 2.5% chance, assuming both parents are eligible to receive a mutation. If multiple mutations occur, they may affect the same or different stats.

How rare is a triple mutation ark? ›

The base chance for a mutation is 7.31%. It is possible to gain a double mutation (+4 in a stat at a 0.184% chance), and it is incredibly rare, but I have also seen a triple mutation (+6 in a stat at a 0.00156% chance).

How much mutagen does a Voidwyrm need? ›

The voidwyrm, or Tek wyvern is a pain to tame. Firstly, you need mutagen, and a lot of it for a high level. On my 5X taming servers, it was roughly 4% per feed.

Is April immune to mutagen? ›

Mutagen Immunity: Being half-Kraang mutant she is immune to mutagen and her blood is the only ingredient needed to perfect the Mutagen (although the Kraang found another way) and Retro-Mutagen.

Can you turn Mutagel into mutagen? ›

How to turn Mutagel into Mutagen. Mutagel can be used to craft Mutagen at a Chemistry Bench. You need 800 units of Mutagel to craft six Mutagen. Mutagen is used for taming Voidwyrms, and can be used to further evolve existing tame creatures.

Are mutagens permanent? ›

Mutations. A gene mutation is a permanent change in the DNA sequence of a gene. Mutations can occur in a single base pair or in a large segment of a chromosome and even span multiple genes. Mutations can result from endogenous (occurring during DNA replication) or exogenous (environmental) factors.

Can you convert Monster mutagens Witcher 3? ›

Alchemy Equipment at Corvo Bianco

Here, Geralt can convert monster mutagens into the basic red, blue, and green variety. The method of conversion works different in the hidden laboratory.

How much mutagen do you need for mutagen? ›

Mutagel can also be crafted into Mutagen at a Chemistry bench, which can be used later to tame Stryders. It takes 800 Mutagel to make 1 Mutagen so make sure you collect lots of it. To get Mutagel from rocks, you can head over to the space area where you can find different rocks depending on the time of the day.

Is mutated skin good Witcher 3? ›

Mutated Skin can turn Geralt into a something of a walking tank as long as you can efficiently generate adrenaline points. This build concentrates on survivability coupled with skills that help you rack up adrenaline points so that you're always taking minimal damage.

What is the most powerful mutagen? ›

Among them, 2-nitrobenzanthrone (2-NBA) and 3-nitrobenzanthrone (3-NBA) are considered as two of the most potent mutagens found in atmospheric particles.

Why is Geralt more mutations? ›

Geralt is a result of his exposure to further mutation, due to his unique tolerance for the Trial of Grasses; this extended process left his hair devoid of pigment and possibly left him even stronger and faster than his brethren.

Can I reset mutations Witcher 3? ›

Potion of Restoration is a special potion introduced in the Blood and Wine expansion. It allows the player to redistribute their ability points that were used for mutations but it does not return the mutagens used, so you'll have to re-gather them to unlock any abilities.

What is the coolest armor in Witcher 3? ›

The best Witcher 3 armor and gear
  • Kaer Morhen Armor/Warrior's Leather Jacket.
  • Viper/Serpentine Gear Set.
  • Griffin Gear Set.
  • Manticore Gear Set.
  • Bear/Ursine Gear Set.
  • Wolf/Wolven Gear Set.
  • Cat/Feline Gear Set.
Dec 16, 2022

What are mutagens 12? ›

“A mutagen is defined as any physical or chemical substance that can change the genetic material of an organism, thereby causing a mutation.”

Is XRAY a mutagen? ›

Hermann Joseph Muller conducted three experiments in 1926 and 1927 that demonstrated that exposure to x-rays, a form of high-energy radiation, can cause genetic mutations, changes to an organism's genome, particularly in egg and sperm cells.

What was Geralt's last wish? ›

Geralt wished to die alongside Yennefer. Since a djinn can't kill its own master, this wish would provide a nice loophole that would save Yennefer's life and also ensure that Geralt and Yennefer's lives are bound together until their very ends.

What is Geralt's disability? ›

Instead, Geralt is riddled with chronic pain throughout the rest of the series. "It affects his gait, causing him to walk with a limp that increases in severity depending on the weather. He finds that riding Roach for long periods is very uncomfortable.

How many survive the witcher mutations? ›

Reportedly, only three in ten survived the trial, but those who did gained lightning quick reflexes in return. The trial was performed in the witchers' laboratory at Kaer Morhen.

Is there a yellow mutagen Witcher 3? ›

Like all the other colored mutagens, the yellow mutagen formulas will be a part of Geralt's alchemy recipes by default. Start a new game or load an existing save to get them.

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