The following things will break the chain
Using your rollerskates or bicycleSee AlsoPath Of Exile: 10 Rarest Orbs/Currencies In The Game And What They DoAssailum | PoE WikiFeedback and Suggestions - The Divine / Exalt Change is awesome. - Forum - Path of ExileTop 5 Maps To Favorite in Path of Exile Lake of KalandraEncountering a different type of pokémon from the one that you started the chain withEncountering a wild pokémon that was not in a shaking patch of grassLeaving the areaSaving and restarting from where you left off
So,you will not break the chain if you save but if you restart your system,it will break.
Source: Guide to chaining.
Hope I helped!